反应详情

温度

0 °C

Stage 1 of the preparation was carried out under an argon atmosphere. To a stirred solution of t butyl alcohol (4.92 g) in tetrahydrofuran (20 ml) at -30° C. was added dropwise n-butyl lithium (41.8 ml of 1.6 molar solution). The resultant lithium t-butoxide solution was allowed to warm to 0° C. and was added to a stirred solution of cuprous iodide (12.65 g) in tetrahydrofuran (50 ml). After about 15 minutes, the grey cuprous iodide was replaced by a beige solid, and the reaction mixture turned brown. The reaction mixture was then cooled to -70° C. and t-butyl lithium (34.0 ml of 1.9 molar solution) was added dropwise. A cooled (-40° C.) solution of 3-cyclohexyl propionic acid chloride (10 .0 g) in tetrahydrofuran (20 ml) was added rapidly. After 11/2 hours, the reaction was quenched by the addition of methanol (30 ml) and the reaction mixture was allowed to stand overnight at room temperature. The mixture was then poured into saturated ammonium chloride (200 ml) and insolubles were filtered off. The aqueous layer was extracted with ether (300 ml) and the extract was washed with 1% sodium thiosulphate solution (200 ml) and then dried over magnesium sulphate in the presence of charcoal. Concentration yielded an amber oil which was distilled to give a colourless liquid (5.56 g) which turned yellow on standing.

1. temperatureThe reaction mixture was then cooled to -70° C.
2. additionwas added rapidly
3. customAfter 11/2 hours, the reaction was quenched by the addition of methanol (30 ml)
4. waitto stand overnight at room temperature
5. additionThe mixture was then poured into saturated ammonium chloride (200 ml) and insolubles
6. filtrationwere filtered off
7. extractionThe aqueous layer was extracted with ether (300 ml)
8. washthe extract was washed with 1% sodium thiosulphate solution (200 ml)
9. dry with materialdried over magnesium sulphate in the presence of charcoal
10. concentrationConcentration
11. customyielded an amber oil which
12. distillationwas distilled