反应详情

1-tert-Butoxycarbonyl-4-[N-methyl-N-(3-(2-methyl-1-propenyl)-2-pyridinyl)amino]-piperidine (XXV, EXAMPLE 27, 1.07 g, 3.1 mmol) is hydrogenated at 20 psi over night using palladium on carbon (10%, 0.1 g) as catalyst. The reaction is filtered, the solvent evaporated and the concentrate is used without further purification, NMR (300 MHz, CDCl3) 0.66, 1.25, 1.34-1.42, 1.50-1.56, 1.72-1.81, 2.28, 2.46, 2.50-2.56, 3.50-3.13, 3.88, 6.70, 7.21 and 7.98.

1. filtrationThe reaction is filtered
2. customthe solvent evaporated
3. customthe concentrate is used without further purification, NMR (300 MHz, CDCl3) 0.66, 1.25, 1.34-1.42, 1.50-1.56, 1.72-1.81, 2.28, 2.46, 2.50-2.56, 3.50-3.13, 3.88, 6.70, 7.21 and 7.98