反应详情

1.85 g of 5-(3-benzyloxyphenyl)-7-[3-(2-(1-imidazolyl)ethoxy)phenyl]-4-aminopyrrolo[2,3-d]-pyrimidine are hydrogenated in a hydrogen atmosphere at normal pressure and about 40° C. for 80 h in 40 ml of THF in the presence of 0.4 g of 5% palladium/carbon. After filtration through Celite and crystallization from ethanol, 5-(3-hydroxyphenyl)-7-[3-(2-(1-imidazolyl)-ethoxy)phenyl]-4-aminopyrrolo[2,3-d]pyrimidine having a melting point of 165°-167° C. is obtained.

1. filtrationAfter filtration
2. customthrough Celite and crystallization from ethanol, 5-(3-hydroxyphenyl)-7-[3-(2-(1-imidazolyl)-ethoxy)phenyl]-4-aminopyrrolo[2,3-d]pyrimidine having a melting point of 165°-167° C.
3. customis obtained