反应详情

A mixture of 1.181 g (3.76 mmol) of 2-[N-methyl-N-(4-nitrophenyl)amino]-4H-pyrido[3,2-e]-1,3-thiazin-4-one obtained in Example 63, 100 ml of DMF and 250 mg of 10% Pd on carbon was stirred in an atmosphere of hydrogen for 6 days. The reaction mixture was then heated so that the compound thus precipitated was dissolved. The insoluble matters were hot-removed by filtration. The solution thus obtained was then allowed to cool to room temperature. The resulting crystal was collected by filtration, washed with THF and then with ethanol, and then dried under reduced pressure to obtain 77 mg of 2-[N-(4-hydroxyaminophenyl)-N-methylamino]-4H-pyrido[3,2-e]-1,3-thiazin-4-one.

1. temperatureThe reaction mixture was then heated so that the compound
2. customthus precipitated
3. dissolutionwas dissolved
4. customThe insoluble matters were hot-removed by filtration
5. customThe solution thus obtained
6. filtrationThe resulting crystal was collected by filtration
7. washwashed with THF
8. dry with materialwith ethanol, and then dried under reduced pressure