反应详情

To a solution of 0.27 g of ethyl 3-(4,6-di-t-butyl-2-methyl-5-trimethylsilyloxy-2,3-dihydrobenzofuran-2-yl)-2-propenoate synthesized in Example 75-1) in 20 ml of ethanol was added a catalytic amount of 10% palladium-carbon, and the mixture was stirred for 48 hours under a hydrogen atmosphere. After the catalyst was filtered off, the filtrate was concentrated and the residue was purified on a short column of silica gel eluting with n-hexane containing 9% ethyl acetate to give 0.27 g of ethyl 3-(4,6-di-t-butyl-2-methyl-5-trimethylsilyloxy-2,3-dihydrobenzofuran-2-yl)propanoate as a colorless viscous liquid.

1. filtrationAfter the catalyst was filtered off
2. concentrationthe filtrate was concentrated
3. customthe residue was purified on a short column of silica gel eluting with n-hexane containing 9% ethyl acetate