反应详情

N-Bromosuccinimide (8.94 g, 50.2 mmol) and 200 mg of 2,2'-azobis(isobutyronitrile) were added to a solution of 15.0 g (47.8 mmol) of 4-(3-chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one in 150 ml of carbon tetrachloride, followed by heating under reflux for 3 hours. The reaction solution was again mixed with 1.28 g (7.17 mmol) of N-bromosuccinimide and 100 mg of 2,2'-azobis(isobutyronitrile), followed by heating under reflux for 1 hour. After cooling to room temperature, insoluble matter was removed by filtration, and the resulting filtrate was mixed with water and extracted with carbon tetrachloride. The organic layer was washed with brine and dried over anhydrous magnesium sulfate. After removing magnesium sulfate by filtration, the filtrate was concentrated under a reduced pressure and the resulting residue was purified by silica gel column chromatography (hexane-ethyl acetate) to give 11.5 g of 7-(1-bromoethyl)-4-(3-chlorophenyl)-1-ethylpyrido[2,3-d]pyrimidin-2(1H)-one in the form of crystals. The yield was 61%.

1. temperatureby heating
2. temperatureunder reflux for 3 hours
3. temperatureby heating
4. temperatureunder reflux for 1 hour
5. custominsoluble matter was removed by filtration
6. additionthe resulting filtrate was mixed with water
7. extractionextracted with carbon tetrachloride
8. washThe organic layer was washed with brine
9. dry with materialdried over anhydrous magnesium sulfate
10. customAfter removing magnesium sulfate
11. filtrationby filtration
12. concentrationthe filtrate was concentrated under a reduced pressure
13. customthe resulting residue was purified by silica gel column chromatography (hexane-ethyl acetate)