反应详情

A mixture of 18.0 g (118 mmol) of 4-hydroxy-2,5-dimethyl-benzenemethanol (Example H), 14.9 g (118 mmol) of benzyl chloride and 18.0 g (1.1×118 mmol) of anhydrous potassium carbonate in 300 mL of acetonitrile is stirred at reflux for 18 hours overnight. The reaction flask and inorganic residue are washed with fresh acetonitrile and the solvent is removed on a rotary evaporator. A diethyl ether solution of the residue is washed with 2×50 mL of 2N potassium hydroxide solution, brine, dried (magnesium sulfate) and evaporated leaving 28.3 g of a pale yellow viscous residue. Distillation through a short path apparatus affords the title compound; mp 58°-59° C.

1. temperatureat reflux for 18 hours overnight
2. washThe reaction flask and inorganic residue are washed with fresh acetonitrile
3. customthe solvent is removed on a rotary evaporator
4. washA diethyl ether solution of the residue is washed with 2×50 mL of 2N potassium hydroxide solution, brine
5. dry with materialdried (magnesium sulfate)
6. customevaporated