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HRID37452

反应详情

EQUATION

反应方程式

HRID 37452 的结构方程式

REACTANTS

反应物

1
结构：CC(=O)OC[C@H]1O[C@@H](Oc2ncccc2C2CCCN2C)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O
HCID15293694

未命名化合物

PRODUCTS

生成物

2
结构：CC(=O)OC[C@H]1O[C@@H](Oc2ncccc2[C@H]2CCCN2C)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O
HCID11027593

未命名化合物

结构：CC(=O)OC[C@H]1O[C@@H](Oc2ncccc2[C@@H]2CCCN2C)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O
HCID11081744

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

The diastereomer mixture (5a) was resolved by means of silica gel column chromatography using ethyl acetate as an eluent. As a result, (S)-(-)-3-(1-methyl-2-pyrrolidinyl)-2-pyridyl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside (6a) and (R)-(+)-3-(1-methyl-2-pyrrolidinyl)-2-pyridyl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside (7a) were obtained in white-solid form and in yields of 1.8 g and 1.7 g, respectively. Further, (S)-(-)-3-(1-methyl-2-pyrrolidinyl)-2-pyridyl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside (6a) and (R)-(+)-3-(1-methyl-2-pyrrolidinyl)-2-pyridyl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside (7a) were each recrystallized from ethyl acetate-hexane. As a result, highly purified (S)-(-)-3-(1-methyl-2-pyrrolidinyl)-2-pyridyl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside (6a) and (R)-(+)-3-(1-methyl-2-pyrrolidinyl)-2-pyridyl 2,3,4,6tetra-O-acetyl-β-D-glucopyranoside (7a) were obtained in yields of 1.7 g (30%) and 1.6 g (28%), respectively.