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HRID375171

反应详情

EQUATION

反应方程式

HRID 375171 的结构方程式

REACTANTS

反应物

2
结构：C[O-].[Na+]
HCID10942334

Methanol, sodium salt

CH3NaO

结构：CCOc1ccc2nc(SC[C@@H](C)Nc3nc(Cl)nc4c3ncn4[C@@H]3O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H]3OC(C)=O)sc2c1
HCID22858307

未命名化合物

PRODUCTS

生成物

1
结构：CCOc1ccc2nc(SC[C@@H](C)Nc3nc(Cl)nc4c3ncn4[C@@H]3O[C@H](COC(C)=O)[C@@H](O)[C@H]3O)sc2c1
HCID22858296

未命名化合物

收率 18%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

Partial deacylation of the purified 2',3',5'-tri-O-acetyl-2-chloro-N-[(R)-1-(6-ethoxy-2-benzothiazolyl)thio-2-propyl]adenosine (described in Example 19) using sodium methoxide in methanol provided the title 5'-O-acetyl-N-[(R)-1-(6ethoxy2-benzothiazolyl)thio-2-propyl]-2-chloroadenosine (0.070 g, 18%) as a foam (following column chromatography), 1H NMR (DMSO-d6) δ 1.34-1.41 (6H, m, --CH2CH3 and --CHCH3), 2.03 (3H, s, --COCH3), 4.60 (1H, q, H-2'), 4.68 (1H, m, -CHCH3), 5.42, 5.62 (2H, 2d, 2'- and 3'-OH), 5.86 (1H, d, H-1'), 7.04 (1H, dd, Ar-H), 7.57, 7.72 (2H, 2d, Ar-H), 8.38 (1H, s, H-8), 8.52 (1H, d, N--H). HPLC retention time 25.6 min [gradient elution, 20-80% acetonitrile/water (containing 0.1% TFA)].