反应详情

To 10 ml of a chloroform solution of 0.23 g (0.5 mmol) of the (R) 1-trifluoromethylpentyl 6-benzyloxy-3,4-dihydro-2-naphthalenecarboxylate obtained in the third step was added 0.1 ml (0.7 mmol) of iodotrimethylsilane in a nitrogen atmosphere with stirring, and the mixture was reacted at room temperature for two and a half hours with stirring. Then, 10 ml of methanol was added, and the mixture was rapidly concentrated at room temperature under reduced pressure. The concentrate was separated by column chromatography, to obtain 0.11 g of (R)1-trifluoromethylpentyl 6-hydroxy-3,4-dihydro-2-naphthalenecarboxylate as a white solid (yield: 61%). The 1H-NMR data of this compound are described below.

1. customthe mixture was reacted at room temperature for two and a half hours
2. stirringwith stirring
3. concentrationthe mixture was rapidly concentrated at room temperature under reduced pressure
4. customThe concentrate was separated by column chromatography