反应详情

A mixture of 10.6 g (45.7 mmol) of 4-chloro-6-nitro-quinoline-3-carbonitrile and 8.82 g (54.8 mmol) of 3-(trifluoromethyl)aniline in 270 mL of ethanol was refluxed under N2 for 5 h. The reaction was diluted with ethanol, neutralized with satd sodium bicarbonate and evaporated. The residue was slurried with hexane, collected, washed with hexane and water and dried in vacuo (60° C.) to give 10.9 g of yellow solid. A 2.00 g sample was recrystallized from ethanol to give 1.20 g of bright yellow solid; mp 260-261° C.

1. temperaturewas refluxed under N2 for 5 h
2. customevaporated
3. customcollected
4. washwashed with hexane and water
5. customdried in vacuo (60° C.)