反应详情

A stirred mixture of 4-[(3-bromophenyl)amino]-8-methyl-6-nitro-quinoline-3-carbonitrile (15.3 g, 40 mmol), 0.37 g (3 mmol) of dimethylaminopyridine, 40 ml of acetic anhydride, and 80 ml of pyridine was refluxed for 3 h and concentrated at 50° C. under vacuum. The residue was stirred with methylene chloride and 0.1 N HCl. After filtration through Celite, the organic layer was washed with water, dried and concentrated. The residue was subjected to chromatography on silica gel with 1% acetic acid in methylene chloride to give 11.2 g of an amber glass, NMR (CDCl3) d 2.29 (N-acetyl group).

1. temperaturewas refluxed for 3 h
2. concentrationconcentrated at 50° C. under vacuum
3. filtrationAfter filtration through Celite
4. washthe organic layer was washed with water
5. customdried
6. concentrationconcentrated