反应详情

A mixture of 3.52 g (9.7 mmol) of 4-chloro-7-methoxy-6-nitro-quinoline-3-carbonitrile and 2.0 g (10.7 mmol) of 3-bromo-4-fluoro aniline in 150 ml of methoxyethanol was refluxed under nitrogen for 5.5 hours. The reaction mixture was diluted with ethyl acetate and wash with sodium bicarbonate solution and sodium chloride solution. The organic layer was dried with sodium sulfate and then solvent was removed under vacuum. The residue was chromatographed on silica gel eluting with mixture of ethyl acetate and hexane to give the title compound.

1. temperaturewas refluxed under nitrogen for 5.5 hours
2. washwash with sodium bicarbonate solution and sodium chloride solution
3. dry with materialThe organic layer was dried with sodium sulfate
4. customsolvent was removed under vacuum
5. customThe residue was chromatographed on silica gel eluting with mixture of ethyl acetate and hexane