反应详情

A mixture of (R)-2-(4,5-diphenyloxazol-2-yl)-1-trimethylsilyloxy-1-[3-(tertbutyldiphenylsiloxy)benzyl]-2-cyclohexene (24 g) and 10% Pd/C (10 g) in a mixture of MeOH (200 ml) and EtOAc (500 ml) was stirred under H2 for 8 hours. The catalyst was filtered off and the filtrate was evaporated in vacuo. The residue was purified by chromatography on silica gel to give (1R, 2S)-2-(4,5-diphenyloxazol-2-yl)-1-trimethylsilyoxy-1-[3-(tertbutyldiphenylsiloxy)benzyl]cyclohexane (21 g).

1. filtrationThe catalyst was filtered off
2. customthe filtrate was evaporated in vacuo
3. customThe residue was purified by chromatography on silica gel