Butyryl chloride → HCID 18368002, compound

HRID 379740Notes

Reaction equation

HRID 379740 reaction equation
[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([Cl:11])=[CH:8][CH:9]=2)[NH:4][C:3]=1[C:12](=[O:20])[C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([Cl:19])[CH:14]=1.[C:21](Cl)(=[O:25])[CH2:22][CH2:23][CH3:24]>>[C:21]([NH:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([Cl:11])=[CH:8][CH:9]=2)[NH:4][C:3]=1[C:12](=[O:20])[C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([Cl:19])[CH:14]=1)(=[O:25])[CH2:22][CH2:23][CH3:24]

Participants

3

Reactant 2

HCID 8855Butyryl chlorideHCID 18368029HCID 18368029, compound

Product 1

HCID 18368002HCID 18368002, compound

Procedure

The title compound was prepared according to the procedure described in Example 19 employing 3-amino-6-chloro-2-(3-chlorobenzoyl)indole (Example 30) and butyryl chloride. m.p.: 157-158° C. 1H-NMR (CDCl3) δ: 9.96 (1H, br s), 8.29 (1H, d, J=8.8 Hz), 8.17 (1H, br s), 7.78 (1H, dd, J=1.5, 1.8 Hz), 7.70-7.59 (2H, m), 7.51 (1H, t, J=7.7 Hz), 7.31 (1H, d, J=1.1 Hz), 7.11 (1H, dd, J=1.8, 8.8 Hz), 2.47 (2H, t, J=7.3 Hz), 1.88-1.75 (2H, m), 1.05 (3H, t, J=7.5 Hz)

Sources & evidence

ORD record
ord-cb87966c259a40e9a5412e564b48f71e
Source dataset
uspto-grants-2001_10
Patent number
US06300363B1

Reaction notes

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