反应详情

A mixture of 2′-chloro-5′-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4′-fluoroacetanilide (24.42 g, 64.3 mmol) in ethanol is treated with 2N hydrochloric acid (200 ml), diluted with tetrahydrofuran, refluxed overnight, cooled to room temperature, partially concentrated in vacuo to remove ethanol and tetrahydrofuran, neutralized with 3N sodium hydroxide solution, and extracted with ethyl acetate. The organic extracts are combined, washed sequentially with saturated sodium hydrogen carbonate solution and brine, dried over anhydrous magnesium sulfate, and concentrated in vacuo to give the title product as a light, brown solid (20.3 g, mp 132-135° C.).

1. temperaturerefluxed overnight
2. concentrationpartially concentrated in vacuo
3. customto remove ethanol and tetrahydrofuran
4. extractionextracted with ethyl acetate
5. washwashed sequentially with saturated sodium hydrogen carbonate solution and brine
6. dry with materialdried over anhydrous magnesium sulfate
7. concentrationconcentrated in vacuo