HRID382150

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C=CCOC(=O)C[C@@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](C(=O)NC)C(C)(C)C

HCID54424559

未命名化合物

结构：CNC(=O)[C@@H](NC(=O)[C@H](N)CC(=O)OCc1ccccc1)C(C)(C)C.O=C(O)C(F)(F)F

HCID70081434

未命名化合物

PRODUCTS

生成物

结构：C=CCOC(=O)C[C@@H](N)C(=O)N[C@H](C(=O)NC)C(C)(C)C.O=C(O)C(F)(F)F

HCID86584409

未命名化合物

收率 87%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21584188

Chloroform methanol

C2H5Cl3O

PROCEDURE

实验过程

As described in Example 1(b) for the preparation of 3(R)-amino-N-(2,2-dimethyl-1(S)-(methylcarbamoyl)propyl)succinamic acid benzyl ester trifluoroacetate salt, crude 3(R)-(t-butoxycarbonylamino)-N-(2,2-dimethyl-1(S)-(methylcarbamoyl)propyl)succinamic acid allyl ester was deprotected after 2 hours. Flash column chromatography with 0.5% TFA17% MeOH/CHCl3 gave 2.46 g (87%) of 3(R)-amino-N-(2,2-dimethyl-1(S)-(methylcarbamoyl)propyl)succinamic acid allyl ester trifluoroacetate salt as a colorless foam.