(1-methyl-1H-1,2,4-triazol-5-yl)methanol → 3-(3-Methylisoxazol-5-yl)-6-(2-methyl-1,2,4-triazol-3-yl)methyloxy-1,2,4-triazolo[3,4-a]phthalazine

HRID 382945Notes

Reaction equation

HRID 382945 reaction equation
[CH3:1][C:2]1[CH:6]=[C:5]([C:7]2[N:11]3[N:12]=[C:13]([O:20][CH2:21][C:22]4C=CC=[CH:24][N:23]=4)[C:14]4[C:19]([C:10]3=[N:9][N:8]=2)=[CH:18][CH:17]=[CH:16][CH:15]=4)[O:4][N:3]=1.C[N:29]1[C:33](CO)=[N:32]C=N1>>[CH3:1][C:2]1[CH:6]=[C:5]([C:7]2[N:11]3[N:12]=[C:13]([O:20][CH2:21][C:22]4[N:23]([CH3:24])[N:29]=[CH:33][N:32]=4)[C:14]4[C:19]([C:10]3=[N:9][N:8]=2)=[CH:18][CH:17]=[CH:16][CH:15]=4)[O:4][N:3]=1

Participants

3

Reactant 2

HCID 11073377(1-methyl-1H-1,2,4-triazol-5-yl)methanolHCID 183618903-(3-Methylisoxazol-5-yl)-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazine

Product 1

HCID 183618643-(3-Methylisoxazol-5-yl)-6-(2-methyl-1,2,4-triazol-3-yl)methyloxy-1,2,4-triazolo[3,4-a]phthalazine

Procedure

The title-compound was prepared from the product of Example 120 part a and 2-methyl-1,2,4-triazole-3-methanol (prepared using the conditions of Itoh and Okongi, EP-A-42120) following the procedure given for Example 98, 1H NMR (400 MHz, CDCB) 8 2.43 (3H, s, CH3), 4.16 (3H, s, CH3), 5.82 (2H, s, CH2), 7.07 (1H, s, Ar—H), 7.84 (1H, m, Ar—H), 7.95-8.04 (2H, m, 2 of Ar—H), 8.21 ilH, d, J=8.0 Hz, Ar—H), 8.62 (1H, d, J=8.0 Hz, Ar—H); MS(ES+) m/e 363 [MH]+; Anal. Found. C, 56.12; H, 3.90; N, 30.74. C17H14N8O2 requires C, 56.35; H, 3.89; N, 30.92%.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-95f823abc8834402b2af6b30050e4754
Source dataset
uspto-grants-2001_10
Patent number
US06310203B1

Reaction notes

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