反应详情

To 1.4 g of tert-butyl (2,3-dihydro-1,4-benzodioxin-6-ylmethyl)(1-(2-(2-oxo-1,8-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)carbamate, 50 mL of a 4 mol/L hydrogen chloride/ethyl acetate solution was added, and the mixture was stirred at room temperature for 1 day. The solvent was distilled off under reduced pressure, thereto was added ethanol, and the solvent was distilled off under reduced pressure. Ethyl acetate was added to the resultant residue, and after stirring, the solid was filtered off to obtain 1.2 g of 1-(2-(4-((2,3-dihydro-1,4-benzodioxin-6-ylmethyl)amino)piperidin-1-yl)ethyl)-1,8-naphthyridin-2(1H)-one hydrochloride as a white solid.

1. distillationThe solvent was distilled off under reduced pressure
2. additionwas added ethanol
3. distillationthe solvent was distilled off under reduced pressure
4. additionEthyl acetate was added to the resultant residue
5. stirringafter stirring
6. filtrationthe solid was filtered off