反应详情

A mixture of ethyl 2-(1-(naphthalen-1-yl)-1H-tetrazol-5-ylthio)acetate (269 mg, 0.86 mmol), aqueous sodium hydroxide solution (10%, 5 mL) and methanol (10 mL) was stirred at reflux for 2 hours. The reaction was then cooled to room temperature and the methanol removed. Water was added, neutralized with aqueous HCl solution (1N) and extracted with ethyl acetate. The organic layer was dried over sodium sulfate and concentrated. Purification by preparative thin layer chromatography (95% dichloromethane/5% methanol) afforded compound 2-(1-(naphthalen-1-yl)-1H-tetrazol-5-ylthio)acetic acid as a solid.

1. temperatureat reflux for 2 hours
2. customthe methanol removed
3. additionWater was added
4. extractionextracted with ethyl acetate
5. dry with materialThe organic layer was dried over sodium sulfate
6. concentrationconcentrated
7. customPurification by preparative thin layer chromatography (95% dichloromethane/5% methanol)