反应详情

The title compound (11e) was prepared from 5-(2-pyridyl)oxazole and 3-(4-(phenoxymethyl)phenyl)propanoic acid (S27) using General Procedure B. PTLC (SiO2, 50% EtOAc-hexanes) afforded 11e (40 mg, 0.10 mmol, 32%) as a pale yellow solid: 1H NMR (CDCl3, 400 MHz) 8.68-8.66 (m, 1H), 7.89 (s, 1H), 7.88-7.85 (m, 1H), 7.81 (td, 1H, J=7.9, 1.5 Hz), 7.38 (d, 2H, J=8.2 Hz), 7.34-7.27 (m, 5H), 6.99-6.94 (m, 3H), 5.03 (s, 2H), 3.48 (t, 2H, J=7.4 Hz), 3.13 (t, 2H, J=7.5 Hz); 13C NMR (CDCl3, 100 MHz) 187.2, 158.7, 157.1, 153.3, 150.1, 146.2, 140.1, 137.1, 137.0, 129.4, 128.6, 127.8, 126.9, 124.1, 120.8, 120.3, 114.7, 69.6, 40.5, 29.3; IR (film) νmax 2923, 1694, 1601, 1504, 1470, 1428, 1380, 1241, 1171, 1125, 1080, 1032, 1017, 989, 962, 911, 869, 815, 788, 760, 693 cm−1; ESI-TOF m/z 385.1550 (C24H20N2O3+H+ requires 385.1547).