反应详情

82 mg of N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-2-(2-ethoxyethyl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide and 1 cm3 of a 2M solution of hydrochloric acid in ethyl ether are stirred at a temperature close to 20° C., under argon. The stirring is stopped and the ethyl ether is drawn off. The paste obtained is dried under vacuum at a temperature of 40° C. 86 mg of N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-2-(2-ethoxyethyl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide hydrochloride (1:1) are obtained in the form of a white powder.

1. customclose to 20° C., under argon
2. customThe paste obtained
3. customis dried under vacuum at a temperature of 40° C