4-Iodo-2-(isoquinolin-5-yl)furo[2,3-c]pyridin-7-amine → HCID 66760274, compound

HRID 389435Notes

Reaction equation

HRID 389435 reaction equation
[S:1]1C2=CN=CC=C2C(C2OC3=CN=CC=C3C=2)=C1.[I:19][C:20]1[CH:25]=[N:24][C:23]([NH2:26])=[C:22]2[O:27][C:28]([C:30]3[CH:39]=CC=[C:36]4[C:31]=3[CH:32]=[CH:33][N:34]=[CH:35]4)=[CH:29][C:21]=12>>[I:19][C:20]1[CH:25]=[N:24][C:23]([NH2:26])=[C:22]2[O:27][C:28]([C:30]3[C:31]4[C:36](=[CH:35][N:34]=[CH:33][CH:32]=4)[S:1][CH:39]=3)=[CH:29][C:21]=12

Participants

3

Reactant 2

HCID 667594744-Iodo-2-(isoquinolin-5-yl)furo[2,3-c]pyridin-7-amineHCID 866623962-Thieno[2,3-c]pyridin-3-yl-furo[2,3-c]pyridin

Product 1

HCID 66760274HCID 66760274, compoundYield 77%

Procedure

The title compound was prepared in 77% yield from 2-thieno[2,3-c]pyridin-3-yl-furo[2,3-c]pyridin]-7-ylamine by a procedure analogous to Intermediate 10, Step B. 1H NMR (300 MHz, CDCl3+CD3OD): δ 6.83 (s, 1H), 7.82 (s, 1H), 8.11 (d, J=5.6 Hz, 1H), 8.26 (s, 1H), 8.44 (d, J=5.8 Hz, 1H), 9.02 (s, 1H).

Sources & evidence

ORD record
ord-590de90999994cdcb12cdb957bfa893d
Source dataset
uspto-grants-2013_02
Patent number
US08378104B2

Reaction notes

Loading…