HRID389548

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cn1cc2c(B3OC(C)(C)C(C)(C)O3)csc2cc1=O

HCID66760098

未命名化合物

结构：CC(C)(C)[Si](C)(C)O[C@H]1CC[C@H](n2cc(-c3cnc(N)c4oc(Cl)cc34)cn2)CC1

HCID178455334

未命名化合物

PRODUCTS

生成物

结构：Cn1cc2c(-c3cc4c(-c5cnn([C@H]6CC[C@H](O)CC6)c5)cnc(N)c4o3)csc2cc1=O

HCID178479900

未命名化合物

收率 60%

PROCEDURE

实验过程

The title compound was prepared in 60% yield from 4-[1-(trans-4-{[tert-butyl(dimethyl)silyl]oxy}cyclohexyl)-1H-pyrazol-4-yl]-2-chlorofuro[2,3-c]pyridin-7-amine and 5-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thieno[3,2-c]pyridin-6(5H)-one by a procedure analogous to Example 229. 1H NMR (400 MHz, CD3OD): δ 8.98 (s, 1 H), 8.11 (s, 1 H), 7.99-8.03 (m, 1 H), 7.87-7.95 (m, 2 H), 7.43-7.52 (m, 1 H), 6.96-7.10 (m, 1 H), 4.16-4.37 (m, 1 H), 3.88 (s, 3 H), 3.61-3.78 (m, 1 H), 1.85-2.31 (m, 6 H), 1.39-1.69 (m, 2 H); MS (ESI): 462.28 [M+H]+; HPLC tR=2.30 min (ZQ3, polar—4 min).

WORKUP

后处理

custom4 min