HRID389580
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
PROCEDURE
实验过程
The title compound was prepared from 4-[1-(trans-4-{[tert-butyl(dimethyl)silyl]oxy}cyclohexyl)-1H-pyrazol-4-yl]-2-chlorofuro[2,3-c]pyridin-7-amine and 6-(3-fluorophenyl)-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-benzothiazole by a procedure analogous to Example 229. 1H NMR (400 MHz, DMSO-d6): δ 9.21 (s, 1H), 8.55 (d, J=7.58 Hz, 1H), 8.28 (s, 1H), 8.07 (s, 1H), 7.98 (s, 1H), 7.97 (s, 1H), 7.79 (d, J=7.83 Hz, 1H), 7.59-7.72 (m, 3H), 7.34-7.43 (m, 1H), 6.34 (br s, 2H), 4.70 (d, J=4.29 Hz, 1H), 4.21 (tt, J=3.98, 11.56 Hz, 1H), 3.49-3.60 (m, 1H), 2.09 (br d, J=12.40 Hz, 2H), 1.83-2.02 (m, 4H), 1.33-1.46 (m, 2H); MS (ESI): 526.08 [M+H]+; HPLC tR=2.37 min (ZQ3: nonpolar—4 min).
WORKUP
后处理
- customHPLC tR=2.37 min (ZQ3: nonpolar—4 min)