反应详情

The title compound was prepared from 4-iodo-2-(phthalazin-5-yl)furo[2,3-c]pyridin-7-amine and 1-[4-(tert-butyldimethylsilanyloxy)-cyclohexyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole by a procedure analogous to Example 365, Step F. 1H NMR (400 MHz, DMSO-d6): δ 10.39 (s, 1H), 9.80 (d, J=1.26 Hz, 1H), 8.65 (d, J=7.33 Hz, 1H), 8.25-8.35 (m, 2H), 8.20 (t, J=7.80 Hz, 1H), 8.05 (s, 1H), 7.98 (s, 1H), 7.93 (s, 1H), 6.54 (br s, 2H), 4.68 (d, J=4.29 Hz, 1H), 4.18 (tt, J=3.73, 11.43 Hz, 1H), 3.48-3.59 (m, 1H), 2.07 (br d, J=12.10 Hz, 2H), 1.81-2.01 (m, 4H), 1.31-1.44 (m, 2H); MS (ESI): 427.01 [M+H]+; HPLC tR=2.38 min (ZQ3: polar—5 min).

1. customHPLC tR=2.38 min (ZQ3: polar—5 min)