反应详情

A solution of tert-butyl 7-bromo-2-(4-methoxybenzyl)-3-oxo-2′,3′-dihydro-1′H-spiro[isoindoline-1,4′-pyridine]-1′-carboxylate (5 g, 0.01 mol) in TFA (50 mL) and CF3SO3H (5 mL) was stirred and heated for 8 h. The mixture was concentrated to give a residue which was washed with aq NaOH and extracted with EtOAc. The organic layer was dried and concentrated to give 7-bromo-2′,3′-dihydro-1′H-spiro[isoindoline-1,4′-pyridin]-3-one (2.0 g, 72%).

1. temperatureheated for 8 h
2. concentrationThe mixture was concentrated
3. customto give a residue which
4. washwas washed with aq NaOH
5. extractionextracted with EtOAc
6. customThe organic layer was dried
7. concentrationconcentrated