反应详情

Under N2, a mixture of [6-(3-aminomethyl-phenoxy)-3-propyl-3,4-dihydro-quinazolin-2-yl]-carbamic acid tert-butyl ester (0.0007 mol) and 2,4,6-trimethyl-benzaldehyde (0.0007 mol) in DCE (10 mL) was stirred at room temperature, then NaBH(OAc)3 (0.2 g) was added, and the reaction mixture was stirred overnight at room temperature. A saturated NaHCO3 solution was added, and the layers were separated. The organic layer was dried, filtered off and the solvent was evaporated. The residue was purified by Biotage column chromatography (gradient eluent: CH2Cl2:CH3OH). The purest product fractions were collected and the solvent was evaporated to yield the title compound as a residue.

1. stirringthe reaction mixture was stirred overnight at room temperature
2. customthe layers were separated
3. customThe organic layer was dried
4. filtrationfiltered off
5. customthe solvent was evaporated
6. customThe residue was purified by Biotage column chromatography (gradient eluent: CH2Cl2:CH3OH)
7. customThe purest product fractions were collected
8. customthe solvent was evaporated