Ethyl formate → tert-Butyl 2-(4-fluorobenzyl)-2-formylhydrazinecarboxylate

HRID 390333Notes

Reaction equation

[F:1][C:2]1[CH:17]=[CH:16][C:5]([CH2:6][NH:7][NH:8][C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])=[CH:4][CH:3]=1.[CH:18](OCC)=[O:19]>CCO>[F:1][C:2]1[CH:17]=[CH:16][C:5]([CH2:6][N:7]([CH:18]=[O:19])[NH:8][C:9]([O:11][C:12]([CH3:13])([CH3:14])[CH3:15])=[O:10])=[CH:4][CH:3]=1

Participants

Conditions

Temperature: 50 °C

Procedure

To a solution of tert-butyl 2-(4-fluorobenzyl)hydrazinecarboxylate (0.6 g, 2.50 mmol, 1.0 equiv) in EtOH (2.5 mL) was added ethyl formate (0.81 mL, 9.99 mmol, 4.0 equiv) and the reaction mixture heated to 50° C. (oil bath). After stirring 4 h, the reaction was cooled to ambient temperature and stirred 3 d. The reaction was then heated to 50° C. (oil bath) for 3 h at which time more ethyl formate (1.0 mL, 12.28 mmol, 4.9 equiv) was added. After stirring a further 4 h, the reaction was concentrated in vacuo. The crude product was purified by silica gel chromatography (elute with 10-70% ethyl acetate/hexane) to provide the title compound (0.11 g, 16% yield) as a colorless oil which slowly crystallized. Unreacted tert-butyl 2-(4-fluorobenzyl)hydrazinecarboxylate was recovered from the mother liquor. 1H NMR (400 MHz, CDCl3) δ ppm 8.20 (s, 1H), 7.20-7.25 (m, 2H), 7.00-7.08 (m, 2H), 6.27 (s, 1H), 4.58 (s, 2H), 1.43 (s, 9H); LCMS (ES+, (M+H)+) m/z 269.22.

Workup

temperaturethe reaction was cooled to ambient temperature
stirringstirred 3 d
additionwas added
stirringAfter stirring a further 4 h
concentrationthe reaction was concentrated in vacuo
customThe crude product was purified by silica gel chromatography (elute with 10-70% ethyl acetate/hexane)

Sources & evidence

ORD record: ord-bd6d75c2933d4cfaa49c7351c50a28c4
Source dataset: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08383639B2

Reaction notes

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