反应详情

The titled compound was prepared as the hydrochloride salt according to Method CB using the product of Example 1A (78 mg, 0.5 mmol) and 4-ethynyl-1-fluoro-2-methylbenzene (Aldrich, 67 mg, 0.5 mmol). 1H NMR (300 MHz, DMSO-d6) δ 1.96 (s, 3H), 7.38 (t, J=9.6 Hz, 1H), 7.62-7.75 (m, 2H), 7.80 (ddd, J=7.9, 5.4, 2.2 Hz, 1H), 7.89 (dd, J=6.9, 1.8 Hz, 1H), 8.42 (dt, J=8.1, 1.8, 1.6 Hz, 1H), 8.79 (dd, J=5.2, 1.6 Hz, 1H), 9.16 (d, J=2.4 Hz, 1H) ppm; MS (DCI/NH3) m/z 255 (M+H)+.