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HRID391795

反应详情

EQUATION

反应方程式

HRID 391795 的结构方程式

REACTANTS

反应物

4
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1
HCID7404

Benzenesulfonyl chloride, 4-nitro-

C6H4ClNO4S

结构：COC(=O)[C@H](Cc1ccc2c(c1)OC[C@H](c1ccc(OC(C)=O)cc1)O2)NC(=O)OC(C)(C)C
HCID58327221

未命名化合物

结构：COC(=O)[C@@H](N)Cc1ccc2c(c1)OC[C@H](c1ccc(OC(C)=O)cc1)O2
HCID67251459

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)[C@H](Cc1ccc2c(c1)OC[C@H](c1ccc(OC(C)=O)cc1)O2)NS(=O)(=O)c1ccc([N+](=O)[O-])cc1
HCID58327066

未命名化合物

PROCEDURE

实验过程

(S)-3-[(S)-2-(4-Acetoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-2-tert-butoxycarbonylamino-propionic acid methyl ester (208 mg) was converted to the HCl salt of (S)-3-[(S)-2-(4-acetoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-2-amino-propionic acid methyl ester according to General Procedure C. This intermediate was further reacted with 4-nitrobenzenesulfonyl chloride as described in General Procedure F to furnish (S)-3-[(S)-2-(4-acetoxy-phenyl)-2,3-dihydro-benzo[1,4]dioxin-6-yl]-2-(4-nitro-benzenesulfonylamino)-propionic acid methyl ester (230 mg). LCMS (m/z): 558.