反应详情

The title compound (110 mg) was prepared from (3S,8S)-3-[4-(3,4-dichloro-benzyloxy)-phenyl]-7-((S)-1-phenyl-propyl)-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinoline-8-carboxylic acid and (S)-2-amino-3-[4-(2,3-dimethyl-pyridin-4-yl)-phenyl]-propionic acid methyl ester dihydrochloride according to General Procedures L and B. LCMS (m/z): 857. 1H NMR (400 MHz, acetone-d6): 8.18 (d, 1H), 7.86 (d, 1H), 7.59 (d, 1H), 7.49 (d, 1H), 7.36 (dd, 1H), 7.23-7.18 (m, 4H), 7.15 (m, 1H), 7.11-7.07 (m, 4H), 6.86 (d, 1H), 6.78-6.72 (m, 4H), 6.61 (s, 1H), 6.52 (s, 1H), 5.03 (s, 2H), 4.93 (dd, 1H), 4.72 (m, 1H), 4.14 (dd, 1H), 3.67 (dd, 1H), 3.54 (dd, 1H), 3.45 (d, 1H), 3.39 (dd, 1H), 3.23 (d, 1H), 3.03 (dd, 1H), 2.89-2.79 (m, 2H), 2.66 (dd, 1H), 2.38 (s, 3H), 2.02 (s, 3H), 1.87-1.75 (m, 1H), 1.72-1.61 (m, 1H), 0.48 (t, 3H).