3-Methylbenzoyl chloride → (S)-2-{[(3S,8S)-3-(4-Cyclohexylmethoxy-phenyl)-7-(3-methyl-benzoyl)-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinoline-8-carbonyl]-amino}-3-[4-(2,3-dimethyl-pyridin-4-yl)-phenyl]-propionic acid

HRID 391989Notes

Reaction equation

HRID 391989 reaction equation
Cl.Cl.C[O:4][C:5](=[O:53])[C@@H:6]([NH:22][C:23]([C@@H:25]1[CH2:34][C:33]2[CH:32]=[C:31]3[O:35][CH2:36][C@H:37]([C:39]4[CH:44]=[CH:43][C:42]([O:45][CH2:46][CH:47]5[CH2:52][CH2:51][CH2:50][CH2:49][CH2:48]5)=[CH:41][CH:40]=4)[O:38][C:30]3=[CH:29][C:28]=2[CH2:27][NH:26]1)=[O:24])[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][N:17]=[C:16]([CH3:20])[C:15]=2[CH3:21])=[CH:10][CH:9]=1.[CH3:54][C:55]1[CH:56]=[C:57]([CH:61]=[CH:62][CH:63]=1)[C:58](Cl)=[O:59]>CCOC(C)=O.C([O-])(O)=O.[Na+]>[CH:47]1([CH2:46][O:45][C:42]2[CH:41]=[CH:40][C:39]([C@H:37]3[CH2:36][O:35][C:31]4=[CH:32][C:33]5[CH2:34][C@@H:25]([C:23]([NH:22][C@@H:6]([CH2:7][C:8]6[CH:9]=[CH:10][C:11]([C:14]7[CH:19]=[CH:18][N:17]=[C:16]([CH3:20])[C:15]=7[CH3:21])=[CH:12][CH:13]=6)[C:5]([OH:53])=[O:4])=[O:24])[N:26]([C:58](=[O:59])[C:57]6[CH:61]=[CH:62][CH:63]=[C:55]([CH3:54])[CH:56]=6)[CH2:27][C:28]=5[CH:29]=[C:30]4[O:38]3)=[CH:44][CH:43]=2)[CH2:52][CH2:51][CH2:50][CH2:49][CH2:48]1

Participants

5

Reactant 2

HCID 743753-Methylbenzoyl chlorideHCID 66719507HCID 66719507, compound

Product 1

HCID 58327433(S)-2-{[(3S,8S)-3-(4-Cyclohexylmethoxy-phenyl)-7-(3-methyl-benzoyl)-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinoline-8-carbonyl]-amino}-3-[4-(2,3-dimethyl-pyridin-4-yl)-phenyl]-propionic acid

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 516892Sodium BicarbonateSolvent

Procedure

(S)-2-{[(3S,8S)-3-(4-cyclohexylmethoxy-phenyl)-2,3,6,7,8,9-hexahydro-[1,4]dioxino[2,3-g]isoquinoline-8-carbonyl]-amino}-3-[4-(2,3-dimethyl-pyridin-4-yl)-phenyl]-propionic acid methyl ester bis hydrochloride (20 mg) was dissolved in 1:1 EtOAc and saturated aqueous NaHCO3 and 3-methylbenzoyl chloride (3 eq) added. After stirring at room temperature 1 hour, the layers were separated and the organic layer was dried over Na2SO4 and evaporated. The residue was purified by over silica (hexanes to 8:2 hexanes-EtOAc to 6:4 hexanes-EtOAc to 6:4 hexanes-EtOAc+2% MeOH to DCM+3% MeOH). The resulting compound was hydrolyzed according to General Procedure B to give the title compound (15 mg). LCMS (m/z): 795.

Workup

  1. additionadded
  2. customthe layers were separated
  3. dry with materialthe organic layer was dried over Na2SO4
  4. customevaporated
  5. customThe residue was purified by over silica (hexanes to 8:2 hexanes-EtOAc to 6:4 hexanes-EtOAc to 6:4 hexanes-EtOAc+2% MeOH to DCM+3% MeOH)

Sources & evidence

ORD record
ord-e9aaa7555adf49039022a87c0c3f4ab6
Source dataset
uspto-grants-2013_02
Patent number
US08383644B2

Reaction notes

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