反应详情

温度

150 °C

A solution 2 4-chloro-6-methoxy-7-(2-([1,2,4]-triazol-1-yl)ethoxy)quinoline (203 mg, 0.66 mmol), (prepared as described for the starting material in Example 38), and 4-chloro-2-fluoroaniline (74 μl, 0.66 mmol) in DMF (10 ml) containing 5M hydrogen chloride in isopropanol (0.4 ml) was heated at 150° C. for 8 hours. The volatiles were removed by evaporation and the residue was partitioned between water and methylene chloride. The aqueous layer was adjusted to pH9 with I M sodium hydroxide. The organic layer was washed with brine, dried (MgSO4) and the volatiles were removed by evaporation. The residue was dissolved in methylene chloride/methanol and 2M ethereal hydrogen chloride (1 ml) was added. After removal of the volatiles by evaporation, the residue was triturated with ether, collected by filtration, washed with ether and dried under vacuum to give 4-(4-chloro-2-fluoroanilino)-6-methoxy-7-(2-([1,2,4]-triazol-1-yl)ethoxy)quinoline hydrochloride (60 mg, 17%).

1. customThe volatiles were removed by evaporation
2. customthe residue was partitioned between water and methylene chloride
3. washThe organic layer was washed with brine
4. dry with materialdried (MgSO4)
5. customthe volatiles were removed by evaporation
6. dissolutionThe residue was dissolved in methylene chloride/methanol
7. addition2M ethereal hydrogen chloride (1 ml) was added
8. customAfter removal of the volatiles
9. customby evaporation
10. customthe residue was triturated with ether
11. filtrationcollected by filtration
12. washwashed with ether
13. customdried under vacuum