反应详情

The title compound was prepared from 5-bromo-7-(1-tert-butyl-1,2,3,6-tetrahydropyridin-4-yl)-1-(2,6-dichlorophenyl)quinolin-2(1H)-one (INTERMEDIATE ABA5) and using 4-chloro-3-fluorophenylboronic acid as described in EXAMPLE ABA11. 1H NMR (CD3OD, 500 MHz) TFA salt: δ 1.415 (s, 9H), 1.813 (dd, J=10.7, 12.8 Hz, 2H), 2.120 (m, 2H), 2.947 (tt, J=3.7, 12.4, 24.7 Hz, 1H), 3.064 (t, J=12.8 Hz, 1H), 3.674 (d, J=12.6 Hz, 2H), 6.490 (s, 1H), 6.736 (d, J=9.8 Hz, 1H), 7.245 (s, 1H), 7.289 (dd, J=1.6, 8.3 Hz, 1H), 7.411 (dd, 1.8, 9.8 Hz, 1H), 7.619 (m, 2H), 7.728 (m, 2H), 7.981 (d, J=9.8 Hz, 1H). Mass spectrum (ESI): 559.5 (M+1).