反应详情

The title compound was prepared from 5-bromo-7-(1-tert-butyl-1,2,3,6-tetrahydropyridin-4-yl)-1-(2,6-dichlorophenyl)quinolin-2(1H)-one (INTERMEDIATE ABA5) and using 3-fluorophenylboronic acid as described in EXAMPLE ABA11. 1H NMR (CD3OD, 500 MHz): δ 1.294 (s, 9H), 1.756 (bs, 2H), 2.015 (bs, 2H), 2.809 (bs, 3H), 3.447 (bs, 2H), 6.480 (s, 1H), 6.713 (d, J=10.1 Hz, 1H), 7.245 (m, 4H), 7.557 (m, 1H), 7.624 (t, J=7.6 Hz, 1H), 7.735 (m, 2H), 7.986 (d, J=10.1 Hz, 1H). Mass spectrum (ESI): 523.5 (M+1).