反应详情

The 7-[(1-tert-butylpiperidin-4-yl)amino]-5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3,4-dihydroquinazolin-2(1H)-one was prepared from 7-[(1-tert-butylpiperidin-4-yl)amino]-5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-3-(4-methoxybenzyl)-3,4-dihydroquinazolin-2(1H)-one by a procedure analogous to that described in COMPOUND CCC3, STEP F. Mass spectrum (ESI) 557 (M+1). Trifluoroacetate salt 1H NMR (500 MHz, CDCl3): selected peaks δ 1.08 (s, 9H); 1.41 (m, 2H); 1.98 (d, J=4.6 Hz, 2H); 2.17 (brs, 2H); 2.96 (d, J=8.7 Hz, 2H); 3.05 (brs, 1H); 4.13 (dd, J=1.8 Hz, J=13.7 Hz, 1H); 4.31 (dd, J=1.1 Hz, J=13.7 Hz, 1H); 5.17 (s, 1H).