反应详情

To a 0.5 M solution of (cyclohexylmethyl)zinc(II) bromide in THF (0.8 mL, 0.4 mmol) was added [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (8 mg, 0.01 mmol) and the reaction was stirred under nitrogen for 20 minutes. 1-(Benzo[d][1,3]dioxol-5-yl)-N-(6-bromopyridin-2-yl)cyclopropanecarboxamide (36 mg, 0.1 mmol) was added and the reaction was irradiated in the microwave for 10 minutes at 150° C. The reaction was quenched with a saturated ammonium chloride solution (2 mL) and a saturated ethylenediamine tetraacetic acid disodium salt solution (2 mL). The mixture was stirred for 30 minutes before it was extracted with dichloromethane (3×4 mL). The organics were dried over Na2SO4 and evaporated. The crude product was dissolved in DMSO (1 mL) and purified by reverse-phase preparative liquid chromatography utilizing a gradient of 0-99% acetonitrile in water containing 0.05% trifluoracetic acid to yield the pure product (20 mg, 0.05 mmol, 50%). ESI-MS m/z calc. 378.19. found 379.1 (M+1)+; retention time 3.55 minutes.

1. customthe reaction was irradiated in the microwave for 10 minutes at 150° C
2. customThe reaction was quenched with a saturated ammonium chloride solution (2 mL)
3. stirringThe mixture was stirred for 30 minutes before it
4. extractionwas extracted with dichloromethane (3×4 mL)
5. dry with materialThe organics were dried over Na2SO4
6. customevaporated
7. dissolutionThe crude product was dissolved in DMSO (1 mL)
8. custompurified by reverse-phase preparative liquid chromatography