HRID395451

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1ccc(NC2CCN(Cc3ccnc(-c4cc(OC)c(OC(C)C)c(OC)c4)c3)CC2)cc1

HCID22557950

未命名化合物

HCID22558034

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(N(Cc2ccnc(-c3cc(OC)c(OC(C)C)c(OC)c3)c2)C2CCN(Cc3ccnc(-c4cc(OC)c(OC(C)C)c(OC)c4)c3)CC2)cc1.Cl.Cl.Cl

HCID18174193

未命名化合物

PROCEDURE

实验过程

4-(p-anisidino)-1-[[2-(3,5-dimethoxy-4-isopropoxyphenyl)pyridin-4-yl]methyl]piperidine (307 mg) and 4-chloromethyl-2-(3,5-dimethoxy-4-isopropoxyphenyl)pyridine (201 mg) were condensed in the same manner as described in Example 9. A free base obtained was converted to a trihydrochloride giving the title compound as yellow powder.

WORKUP

后处理

customcondensed in the same manner
customA free base obtained

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-71c78cdfaa5d421bb3cbb816cd5f7559
来源数据集: uspto-grants-2003_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06605620B1
来源说明: uspto-grants-2003_08

反应 SMILES

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][C:17]3[CH:22]=[CH:21][N:20]=[C:19]([C:23]4[CH:28]=[C:27]([O:29][CH3:30])[C:26]([O:31][CH:32]([CH3:34])[CH3:33])=[C:25]([O:35][CH3:36])[CH:24]=4)[CH:18]=3)[CH2:12][CH2:11]2)=[CH:5][CH:4]=1.[Cl:37][CH2:38][C:39]1[CH:44]=[CH:43][N:42]=[C:41]([C:45]2[CH:50]=[C:49]([O:51][CH3:52])[C:48]([O:53][CH:54]([CH3:56])[CH3:55])=[C:47]([O:57][CH3:58])[CH:46]=2)[CH:40]=1>>[ClH:37].[ClH:37].[ClH:37].[CH3:30][O:29][C:27]1[CH:28]=[C:23]([C:19]2[CH:18]=[C:17]([CH2:16][N:13]3[CH2:12][CH2:11][CH:10]([N:9]([CH2:38][C:39]4[CH:44]=[CH:43][N:42]=[C:41]([C:45]5[CH:50]=[C:49]([O:51][CH3:52])[C:48]([O:53][CH:54]([CH3:56])[CH3:55])=[C:47]([O:57][CH3:58])[CH:46]=5)[CH:40]=4)[C:6]4[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=4)[CH2:15][CH2:14]3)[CH:22]=[CH:21][N:20]=2)[CH:24]=[C:25]([O:35][CH3:36])[C:26]=1[O:31][CH:32]([CH3:33])[CH3:34]