反应详情

温度

0 °C

Sodium hydride (4.08 g of a 60% dispersion in mineral oil, 0.10 mole) was washed with hexanes three times (10 mL each) and suspended in dimethylformamide (50 mL). The stirred suspension was cooled in an ice bath, then 3-nitro-2-hydroxypyridine (13.0 g, 0.093 mole) was added in small portions over a 45-minute period. After the addition was complete, the reaction was stirred at 0° C. for 10 minutes, then room temperature for 30 minutes. The reaction mixture was recooled in an ice bath. Ethyl bromoacetate (0.75 mL, 0.097 mole) was added. The reaction was stirred at 0° C. for 1 hour, then 1.5 hours at room temperature. The reaction mixture was partitioned between ethyl acetate (200 mL) and water (200 mL). The aqueous layer was extracted with ethyl acetate (3×200 mL). The combined organic extracts were washed with water (4×100 mL), brine, and dried over anhydrous sodium sulfate. The solvent was removed under vacuum to afford 15.7 g (75% yield) of the title compound as yellow solid. Rf=0.30 (silica gel, 20% ethyl acetate in dichloromethane).

1. washSodium hydride (4.08 g of a 60% dispersion in mineral oil, 0.10 mole) was washed with hexanes three times (10 mL each)
2. temperatureThe stirred suspension was cooled in an ice bath
3. additionAfter the addition
4. waitroom temperature for 30 minutes
5. customThe reaction mixture was recooled in an ice bath
6. stirringThe reaction was stirred at 0° C. for 1 hour
7. custom1.5 hours
8. customat room temperature
9. customThe reaction mixture was partitioned between ethyl acetate (200 mL) and water (200 mL)
10. extractionThe aqueous layer was extracted with ethyl acetate (3×200 mL)
11. washThe combined organic extracts were washed with water (4×100 mL), brine
12. dry with materialdried over anhydrous sodium sulfate
13. customThe solvent was removed under vacuum