反应详情

A mixture of 2-benzenesulfonyl-6-benzyloxy-1-[4-(2-pyrrolidin-1-yl-ethoxy)phenyl]-1,2,3,4-tetrahydroisoquinoline (0.043 g, 0.08 mmol), ammonium formate (0.096 g, 1.52 mmol), and 20% Pd(OH)2/C (0.025 g) in MeOH (10 ml) was refluxed under N2 for 1 hr, then filtered through Celite. The filtrate was evaporated in vacuo to a white residue that was dissolved in CH2Cl2 (10 ml) and washed with 1M NaOH (5 ml). The aqueous layer was extracted with CH2Cl2 (3×10 ml), and all of the combined organic solutions were dried over MgSO4 and concentrated in vacuo to give 0.026 g (72% yield) of colorless residue.

1. temperaturewas refluxed under N2 for 1 hr
2. filtrationfiltered through Celite
3. customThe filtrate was evaporated in vacuo to a white residue that
4. dissolutionwas dissolved in CH2Cl2 (10 ml)
5. washwashed with 1M NaOH (5 ml)
6. extractionThe aqueous layer was extracted with CH2Cl2 (3×10 ml)
7. dry with materialall of the combined organic solutions were dried over MgSO4
8. concentrationconcentrated in vacuo