反应详情

A mixture of 4-(3-chloro-4-fluoro-phenylamino)-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one (70 mg, 0.25 mmol), (5-formyl-2,4-dimethyl-1H-pyrrol-3-yl)-acetic acid (54.3 mg, 0.3 mmol) and piperidine (3 drops) in ethanol (2 mL) was stirred at room temperature for 1 day. The reaction was concentrated, the residue was suspended in 1N HCl. The precipitate was filtered, washed with water, suspended in hot ethyl acetate, filtered and dried to give 42 mg (38%) of the title compound. 1H NMR (300 MHz, DMSO-d6) δ 13.21 (br s, 1H, NH), 12.17 (br s, 1H, COOH), 11.65 (s, 1H, NH), 9.13 (s, 1H), 8.26 (s, 1H), 7.71 (m, 1H), 7.3-7.4 (m, 3H), 3.37 (s, 2H, CH2), 2.3 (s, 3H, CH3), 2.10 (s, 3H, CH3). MS 442 [M++1].

1. concentrationThe reaction was concentrated
2. filtrationThe precipitate was filtered
3. washwashed with water
4. filtrationfiltered
5. customdried