Hydrogen chloride-ethyl acetate → Carbostyrilhydrochloride

HRID 39812Notes

Reaction equation

HRID 39812 reaction equation
O1C2C=CC(CN(C3CCN(CC[N:28]4[C:37]5[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=5)[CH:31]=[CH:30][C:29]4=[O:38])CC3)C(=O)OC(C)(C)C)=CC=2OCC1.[ClH:39].C(OCC)(=O)C>>[ClH:39].[NH:28]1[C:37]2[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=2)[CH:31]=[CH:30][C:29]1=[O:38]

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 59397846HCID 59397846, compound

Product 1

HCID 18755291Carbostyrilhydrochloride

Procedure

To 0.13 g of tert-butyl (2,3-dihydro-1,4-benzodioxin-6-ylmethyl)(1-(2-(2-oxoquinolin-1(2H)-yl)ethyl)piperidin-4-yl)carbamate, 10 mL of 4 mol/L hydrogen chloride/ethyl acetate solution was added, and left to stand at room temperature for 3 days. The solvent was removed under reduced pressure, 2-propanol was added to the residue obtained and the solvent was removed under reduced pressure. Ethyl acetate was added to the residue thus obtained and the resulting solid was filtered to afford 0.10 g of 1-(2-(4-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)amino)piperidin-1-yl)ethyl)-quinolin-2(1H)one hydrochloride as a yellow solid.

Workup

  1. waitleft
  2. customThe solvent was removed under reduced pressure, 2-propanol
  3. additionwas added to the residue
  4. customobtained
  5. customthe solvent was removed under reduced pressure
  6. additionEthyl acetate was added to the residue
  7. customthus obtained
  8. filtrationthe resulting solid was filtered

Sources & evidence

ORD record
ord-a1ef0495ba5243ca90991a86a0fccf5a
Source dataset
uspto-grants-2013_09
Patent number
US08524738B2

Reaction notes

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