Methanol → HCID 67538254, compound

HRID 39842Notes

Reaction equation

HRID 39842 reaction equation
CO.[CH:3]1([O:6][C:7]2[CH:16]=[C:15]3[C:10]([C:11]([CH3:45])=[CH:12][C:13](=[O:44])[N:14]3[CH2:17][CH2:18][N:19]3[CH2:24][CH2:23][CH:22]([N:25]([CH2:33][C:34]4[CH:43]=[CH:42][C:37]5[O:38][CH2:39][CH2:40][O:41][C:36]=5[CH:35]=4)C(=O)OC(C)(C)C)[CH2:21][CH2:20]3)=[CH:9][CH:8]=2)[CH2:5][CH2:4]1.[ClH:46].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:46].[CH:3]1([O:6][C:7]2[CH:16]=[C:15]3[C:10]([C:11]([CH3:45])=[CH:12][C:13](=[O:44])[N:14]3[CH2:17][CH2:18][N:19]3[CH2:20][CH2:21][CH:22]([NH:25][CH2:33][C:34]4[CH:43]=[CH:42][C:37]5[O:38][CH2:39][CH2:40][O:41][C:36]=5[CH:35]=4)[CH2:23][CH2:24]3)=[CH:9][CH:8]=2)[CH2:4][CH2:5]1

Participants

5

Reactant 3

HCID 887MethanolHCID 21866389Hydrogen chloride-ethyl acetate2×HCID 59398059HCID 59398059, compound

Product 1

HCID 67538254HCID 67538254, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To 1 mL of methanol solution containing 85 mg of tert-butyl (1-(2-(7-cyclopropoxy-4-methyl-2-oxoquinolin-1(2H)-yl)ethyl)piperidin-4-yl)(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)carbamate, 1 mL of 4 mol/L hydrogen chloride/ethyl acetate solution was added at room temperature, and stirred for 1.5 hours. 1 mL of 4 mol/L hydrogen chloride/ethyl acetate solution was added, and further stirred for 30 min. Ethyl acetate was added, and the resulting solid was filtered to give 60 mg of 7-cyclopropoxy-1-(2-(4-((2,3-dihydro-1,4-benzodioxin-6-ylmethyl)amino)piperidin-1-yl)ethyl)-4-methylquinolin-2(1H)-one hydrochloride as a white solid.

Workup

  1. additionwas added at room temperature
  2. stirringfurther stirred for 30 min
  3. filtrationthe resulting solid was filtered

Sources & evidence

ORD record
ord-df732d4135924882a5a74515f64fd1b8
Source dataset
uspto-grants-2013_09
Patent number
US08524738B2

Reaction notes

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