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HRID399098

反应详情

EQUATION

反应方程式

HRID 399098 的结构方程式

REACTANTS

反应物

4
结构：COc1ccc(C=O)cc1
HCID31244

4-Methoxybenzaldehyde

C8H8O2

结构：CC(C)(C)OC(=O)N[C@@H](COCc1ccccc1)C(=O)O
HCID90234

L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)-

C15H21NO5

结构：O=C(N[C@@H](Cc1ccccc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
HCID978331

未命名化合物

结构：CC(C)N=C=NC(C)C.On1nnc2cccnc21
HCID131720865

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc(CN2C(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H]2COCc2ccccc2)cc1
HCID57303670

未命名化合物

PROCEDURE

实验过程

TentaGel resin was coupled with FmocPhe (Mitsunobu conditions) and reductively alkylated with anisaldehyde. BocSer(OBzl) was coupled with HOAt/DIC and after Boc-deprotection the DKP formed in 4% TEA/toluene (12 h). Yield: 7.1 mg (8.3%). 1H-NMR (400 MHz, CDCl3): δ=1.60 (dd, J=6.4, 6.4 Hz, 1 H), 3.22 (dd, J=3.4, 10.0 Hz, 1 H), 3.28 (dd, J=2.8, 10.0 Hz, 1 H), 3.44 (dd, J=2.2, 6.4 Hz, 1 H), 3.81 (s, 3 H), 3.85 (d, J=14.6 Hz, 1 H), 4.07 (dd, J=2.2, 6.4 Hz, 1 H), 4.18 (dd, J=2.8 3.4 Hz, 1 H), 4.21 (d, J=8.0 Hz, 1 H), 4.25 (d, J=8.0 Hz, 1 H), 5.54 (d, J=14.6 Hz, 1 H), 6.42 (broad s, 1 H), 6.87-6.89 (m, 2 H), 7.19-7.40 (m, 12 H). 13C-NMR (101 MHz, CDCl3): δ=36.6, 46.5, 55.8, 59.0, 72.1, 73.5, 114.6, 126.9, 127.8, 128.0, 128.2, 128.7, 129.1, 130.2, 130.5, 135.2, 137.4, 159.8, 163.5, 166.7. Anal. Calcd. for C27H28 N2O4.2H2O: C, 67.48; H, 6.71; N, 5.83, found: C, 68.00; H, 6.18; N, 5.65.