反应详情

A stirred solution of 123 g (0.80 mole) of 5-chloroindoline, 134 g (0.70 mole) of 1,4-dichloronitrobenzene and 97 g (0.80 mole) of collidine in 1000 ml of dimethylformamide was heated under nitrogen at 150° C. for 48 hours. The mixture was then cooled, filtered from some insolubles, and the solvent was removed in vacuo with warming. The residue was partitioned between 1000 ml of dichloromethane and 500 ml of water. The water layer was removed and the organic phase was washed twice with 2N-hydrochloric acid, once with 2N-sodium hydroxide, once more with water, dried over Na2SO4 and concentrated to an oil weighing 230 g. This was dissolved in 170 ml of methanol and stirred at room temperature and then at 0° C. The resultant crystals were collected, washed well with cold methanol, and dried. This afforded 86.5 g (40% yield) of product, m.p. 130°-133° C. 4 g of 5-chloro-1-(4-chloro-2-nitrophenyl)indoline were recrystallized from methanol in 85% yield (overall yield: 34%); m.p. 133°-135° C.

1. temperatureThe mixture was then cooled
2. filtrationfiltered from some insolubles
3. customthe solvent was removed in vacuo
4. temperaturewith warming
5. customThe residue was partitioned between 1000 ml of dichloromethane and 500 ml of water
6. customThe water layer was removed
7. washthe organic phase was washed twice with 2N-hydrochloric acid, once with 2N-sodium hydroxide, once more with water
8. dry with materialdried over Na2SO4
9. concentrationconcentrated to an oil
10. dissolutionThis was dissolved in 170 ml of methanol
11. customat 0° C
12. customThe resultant crystals were collected
13. washwashed well with cold methanol
14. customdried