HCID 178510114, compound → 7-fluoro-N'-hydroxy-3H-benzimidazole-5-carboximidamide

HRID 400719Notes

Reaction equation

HRID 400719 reaction equation
[OH:1][N:2]=[C:3]([C:5]1[CH:13]=[CH:12][C:8]2[NH:9][CH:10]=[N:11][C:7]=2[CH:6]=1)[NH2:4].[F:14]C1C2NC=NC=2C=C(C#N)C=1>>[F:14][C:12]1[C:8]2[NH:9][CH:10]=[N:11][C:7]=2[CH:6]=[C:5]([C:3](=[N:2][OH:1])[NH2:4])[CH:13]=1

Participants

3

Reactant 2

HCID 178510114HCID 178510114, compoundHCID 178513241N'-hydroxy-3H-benzimidazole-5-carboximidamide

Product 1

HCID 1785133677-fluoro-N'-hydroxy-3H-benzimidazole-5-carboximidamide

Procedure

The title compound was prepared following the procedure described for Intermediate 1, step 2, but starting from 7-fluoro-1H-benzimidazole-5-carbonitrile obtained in step 2 (750 mg; 4.65 mmol) as a beige solid (814 mg, 90%). 1H NMR (DMSO-d6) δ 12.88 (bs, 1H), 9.67 (s, 1H), 9.30 (s, 1H), 7.68 (s, 1H), 7.33-7.29 (m, 1H), 5.89 (s, 2H). LC/MS (Method B): 195.1 (M+H)+.

Sources & evidence

ORD record
ord-ae3f40dba28e4e69a8c0567ee3c73fd8
Source dataset
uspto-grants-2014_06
Patent number
US08741923B2

Reaction notes

Loading…