反应详情

A solution of 6-trifluoromethyl-benzo[b]thiophene-2-carboxylic acid 14a (2.031 mmol, 0.50 g) in THF (8 mL) at −70° C. was treated with a 1.6 M solution of n-BuLi in hexanes (2.66 mL, 4.26 mmol). After 1 h at −70° C., N-fluorobenzenesulfonimide (0.833 g, 2.64 mmol) in THF (2 mL) was slowly added and the reaction was warmed to room temperature. After 1 h the mixture was partitioned between dilute aqueous HCl and EtOAc. The organic layer was washed with water and brine and then concentrated. The residue was triturated with CH2Cl2. The off-white precipitate was collected by filtration to provide compound 14b.

1. customAfter 1 h the mixture was partitioned between dilute aqueous HCl and EtOAc
2. washThe organic layer was washed with water and brine
3. concentrationconcentrated
4. customThe residue was triturated with CH2Cl2
5. filtrationThe off-white precipitate was collected by filtration