HCID 71766083, compound → N-[6-Chloro-4-(2-methoxy-pyridin-3-yl)-pyridazin-3-yl]-3-methanesulfonyl-N-methyl-5-trifluoromethyl-benzamide

HRID 403385Notes

Reaction equation

HRID 403385 reaction equation
ClC1N=[N:6]C(NC)=C(C2C(OC)=NC=CC=2)C=1.[Cl:18][C:19]1[N:24]=[N:23][C:22]([N:25]([CH3:42])[C:26](=[O:41])[C:27]2[CH:32]=[C:31]([C:33]([F:36])([F:35])[F:34])[CH:30]=[C:29]([S:37]([CH3:40])(=[O:39])=[O:38])[CH:28]=2)=[C:21]([C:43]2[CH:48]=[CH:47][C:46](F)=C[C:44]=2[O:50][CH3:51])[CH:20]=1>CCCCCCC.C(OCC)(=O)C>[Cl:18][C:19]1[N:24]=[N:23][C:22]([N:25]([CH3:42])[C:26](=[O:41])[C:27]2[CH:32]=[C:31]([C:33]([F:34])([F:35])[F:36])[CH:30]=[C:29]([S:37]([CH3:40])(=[O:38])=[O:39])[CH:28]=2)=[C:21]([C:43]2[C:44]([O:50][CH3:51])=[N:6][CH:46]=[CH:47][CH:48]=2)[CH:20]=1

Participants

4

Reactant 2

HCID 71766083HCID 71766083, compound2×HCID 866984796-chloro-4-(2-methoxypyridin-3-yl)-N-methylpyridazin-3-amine

Product 1

HCID 71766227N-[6-Chloro-4-(2-methoxy-pyridin-3-yl)-pyridazin-3-yl]-3-methanesulfonyl-N-methyl-5-trifluoromethyl-benzamide

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

The title compound was prepared in analogy to example 1, from [6-chloro-4-(2-methoxy-pyridin-3-yl)-pyridazin-3-yl]-methyl-amine and 3-methanesulfonyl-5-trifluoromethyl-benzoic acid (example 1, intermediate d) after a reaction time of 27 hours and using a gradient of n-heptane:ethyl acetate (100:0 to 20:80) for the chromatographic purification. Light yellow solid (10%). MS (ESI+): m/z=501.060 ([M+H]+).

Workup

  1. customfor the chromatographic purification

Sources & evidence

ORD record
ord-baefce9766ba4ec6b9ca75ed02bbb744
Source dataset
uspto-grants-2014_06
Patent number
US08748434B2

Reaction notes

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