HRID404220

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1cccc(-c2cc(CC[C@](C)(C(=O)O)S(C)(=O)=O)on2)c1F

HCID70817723

(2R)-4-[3-(2-Fluoro-3-methoxyphenyl)isoxazol-5-yl]-2-methyl-2-(methylsulfonyl)butanoic acid

C16H18FNO6S

结构：CCOC(=O)[C@@](C)(CCc1cc(-c2cccc(OC)c2F)on1)S(C)(=O)=O

HCID86709152

未命名化合物

PRODUCTS

生成物

结构：COc1cccc(-c2cc(CC[C@](C)(C(=O)O)S(C)(=O)=O)no2)c1F

HCID70817509

未命名化合物

收率 99.1%

PROCEDURE

实验过程

The title compound (0.46 g, 95%) was prepared from ethyl(2R)-4-[5-(2-fluoro-3-methoxyphenyl)isoxazol-3-yl]-2-methyl-2-(methylsulfonyl)butanoate (0.50 g, 1.25 mmol) by following the procedure described for the synthesis of (2R)-4-[3-(2-fluoro-3-methoxyphenyl)isoxazol-5-yl]-2-methyl-2-(methylsulfonyl)butanoic acid (Example 1, Step B). MS (GCMS) m/z 372.1 (M+1). 1H NMR (400 MHz, METHONAL-d4) δ1.69 (s, 3H) 2.45-2.56 (m, 2H) 3.14 (d, J=9.95 Hz, 5H) 3.93 (s, 3H) 6.70-6.82 (m, 1H) 7.19-7.30 (m, 2H) 7.37-7.52 (m, 1H).